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PREGNENOLONE Pregnenolone is the precursor of many steroids and as such is eventually converted into a multitude of steroids and neurosteroids. Pregnenolone was discovered in a 1995 clinical study to be the most potent memory enhancing sterone, possibly 100 times more effective for memory than DHEA. Pregnenolone has been in use for the treatment of arthritis since the 1940's and although it had fallen into disuse for that purpose, its safety record and low toxicity is impressive. In animals, pregnenolone levels are clearly related to cognitive performance, the higher the level the better the performance. As with DHEA, pregnenolone levels decline with age, dosages vary widely; a broad spectrum of studies would indicate anti-aging daily doses of 10mg to 30mg (maximum 50mg). Arthritis doses of 100mg to 200mg and as high as 300mg to 500mg for senile dementia. Pregnenolone can convert into any number of different metabolites and there isn't at present a surefire way of ensuring the ones you want and the ones you may not want. As such, it is possible that some of pregnenolone will convert into DHEA, and either as a result or more directly into testosterone, (although in our experience pregnenolone is less likely to convert into testosterone than DHEA). "Now I have the energy to leave my wheelchair for long
periods. Although I am taking a combination of products including your Idebenone
and ATP I feel that its the Pregnenolone that plays a biggest role in my ability
to live a near-normal day, many many thanks and keep up the good work." |
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