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Hi Ho Silver Away!
(Mild Silver Protein and its effectiveness against internal and topical
infections)
by James South MA.
Silver (Ag) is atomic element number 47, with an atomic
weight of 108. Unlike its heavy metal cousins, Silver is
surprisingly non-toxic to humans and animals and has a long history of successful medical and public health use dating back
6000 years!
Silver has been used to speed wound healing, treat infections,
purify water and preserve beverages. For example, the ancient Macedonians
covered wounds with silver plates to speed healing (1), and N.R. Thompson has
noted that "The germicidal properties of silver, although not recognized as
such, have been utilized since the times of the ancient Mediterranean and
Asiatic cultures, references being made to the use of silver vessels to prevent
spoilage of beverages, and silver foil or plates in the surgical treatment of
wounds and broken bones."(2)
The modern era of
Silver usage began in 1893, when C. Von Nageli
reported the first systematic investigation into the lethal effects of metals
[especially silver] towards bacteria and lower life forms.... To primitive life
forms oligodynamic silver is as toxic as the most powerful chemical
disinfectants and this, coupled with its relative harmlessness to [animal] life,
gives it great potential as a disinfectant.... The term 'oligodynamic'[silver
refers to] solutions in which the metal ion concentration is many orders of
magnitude below that which would be lethal to higher life forms."(2)
From 1900 to the beginning of the modern antibiotic era -
circa 1940 with the introduction of sulfa drugs - Silver was one of the mainstays of
medical practice in Europe and America. Various forms of Silver were used to treat
literally hundreds of ailments: lung infections such as pneumonia, tuberculosis
and pleurisy (3); sexual diseases such as gonorrhea and syphillis (4); skin
conditions such as cuts, wounds, leg ulcers, pustular eczema, impetigo and boils
(4); acute meningitis and epidemic cerebro-spinal meningitis (3); infectious
diseases such as Mediterranean fever, erysipelas, cystitis, typhus, typhoid
fever, and tonsilitis (3); eye disorders such as dacryocystitis, corneal ulcers,
conjunctivitis and blepharitis (5); and various forms of septicemia, including
puerperal fever, peritonitis and post-abortion septicemia (3,6). (This list does
not even begin to exhaust the published medical uses for Silver in Europe and
America, 1900-1940).
In 1939 Hill and Pillsbury listed 94 different proprietary
Silver
preparations in use up to that time (7). However, with the coming of the
antibiotic era, Silver rapidly fell into disuse and the medical 'memory hole', as it
was replaced first by sulfa drugs, then penicillin (post WWII), and since then
by hundreds of specialized antibiotics.
Under the onslaught of antibiotic warfare, the second half of
the 20th century witnessed the seeming eradication, or at least control, of most
of mankind's ancient plague scourges. Indeed some major infectious diseases have
been virtually wiped out in the modern world, (supposedly) thanks to
antibiotics. By the late 1980's, antibiotics had so succeeded in
controlling/eradicating most germ diseases, that medical researchers and
pharmaceutical companies seriously slowed research into new antibiotics,
thinking that there was no longer any need for (and not nearly enough 'big
bucks' to be made from) newer and better antibiotics. Yet by the 1990's the
picture began to change again.
Due to an antibiotic-accelerated Darwinian evolution of
microbes, more and more germ species previously controlled by antibiotics began
to develop ways to combat antibiotics. This in turn gave rise to so-called
'super-germs', such as killer E. coli, 'flesh-eating' strep A bacteria, multiple
antibiotic-resistant tuberculosis bacteria and chloroguine-resistant malarial
parasites (8,9). The overprescription of antibiotics by doctors under pressure
from their patients, for ailments where they are useless (e.g. against common
viral diseases such as cold and flu); the failure of patients to take the full
course of their prescribed antibiotics (allowing germs to recover and develop
antibiotic resistance); and the widespread use of low-level antibiotics in
animal feed to increase farmer's profits (40% of U.S. antibiotics go into animal
feed), have all helped create antibiotic-resistant bacteria (8,9).
Some common (and dangerous) germs such as Staph aureus (found
especially in hospitals) are now known to be resistant to all but one
antibiotic-vancomycin - and soon are expected to be vancomycin-resistant too
(8,9). "In 1992, 13,300 hospital patients died [in the U.S.] of bacterial
infections that resisted the antibiotics fired at them, says the CDC (8)."
Thanks to NAFTA, widespread international air travel,
eco-tourism to exotic third-world forests and islands, and massive migration of
third-world peoples to Europe and America, hosts of exotic diseases once
isolated to small areas of the planet are now showing up all over (8,9). Malaria
is once again returning to the U.S. The exotic and deadly Ebola virus has broken
out in a lab in Maryland. Shigella (which causes dysentery) was
practically unheard of in America before 1990, but it is now being spread from
contaminated fruits and vegetables imported into the U.S. under NAFTA, and is
now routinely seen at clinics in California.
Perhaps the scariest scenario that may present a need for a
powerful, broad-spectrum antimicrobial such as Silver is the late 1990's threat of 'bioterrorism.'
It is now widely expected by biowarfare and terrorism experts that, whether due
to small groups of terrorists, or as a form of warfare by 'rogue'/totalitarian
nations such as China, Iran, Libya, N. Korea, Syria, or Russia, it is only a
matter of time before 'germ warfare' is unleashed in Europe or America (10).
And
if the supergerms released have been produced in sophisticated biowarfare labs,
they will probably have been genetically altered to make them resistant to the
antibiotics normally used to treat that species of germ - e.g. tetracycline/doxycycline
normally used to treat Anthrax (the number 1 favorite of 'biowarfare warriors'
world-wide) (10). It is interesting to note that silver - both in liquid
solution and as an airborne-aerosol - has been known since 1887 to be extremely
toxic to Anthrax spores (1,10,11,12). And it is widely reported in the medical
literature on Silver that various forms of Silver, often at surprisingly low
concentrations, routinely kills germs that are known to be antibiotic-resistant
(11,13,19,20).
Most antibiotics have an optimal effectiveness against only a
few different disease germs; even broad-spectrum antibiotics may kill only 10-20
different types of bacteria. Also, most antibiotics that kill bacteria will not
kill fungus/yeasts, protozoal parasites or viruses; antifungal antibiotics will
not kill bacteria, viruses, parasites, etc. And virtually all known viruses are
immune to virtually all known antibiotics.
Silver is unique among antimicrobial agents in its broad spectrum
of action. It has been claimed to kill some 650 different disease organisms
(13). And unlike antibiotics, Silver is an 'equal opportunity destroyer' - it
doesn't discriminate, but effectively kills germs of all major types:
gram-positive and gram-negative bacteria, spore-forming bacteria, fungus/yeasts,
viruses and protozoal parasites. Silver sulfadiazine (Silvadeneâ), used almost
universally in hospitals to prevent serious burn infections (11), kills dozens
of different bacteria (11,14,16); it also kills 95% of 72 strains of herpesvirus
(15), as well as the protozoal parasite Plasmodium berghei (malaria) (17).
Silvadeneâ also kills various yeasts, including several Aspergillus varieties,
Mucor pusillus, Rhizopus nigricans and 50 different clinical isolates of Candida
albicans (18).
Electrically-generated colloidal silver [Ag(e)] has been
shown to kill dozens of bacteria, including Providencia stuartii, a germ already
resistant in the 1970's to all antibiotics except amikacin (19), as well as two
strains of Enterobacter cloacae that were isolated from burn patients and were
relatively resistant even to Silvadeneâ (20). Ag(e) has also proved adept at
killing various yeast/fungus species at very low Silver concentrations, including
Candida albicans, C. parapsilosis, C. tropicalis, C. pseudotropicalis,
Torulopsis glabrata and Aspergillus niger (20,23).
Ag(e) has been shown to kill cysts of the common water-borne
protozoal parasite Entamoeba histolytica (22). Ag(e) has also killed the
protozoa Paramecium when exposed to 2.2 PPM Silver, as well as the protozoa
Varicella at 5.9 PPM Silver (1).
Ag(e) was even somewhat effective in killing Poliovirus in
swimming pool water, at the extremely low concentration of 0.015mg Silver per liter
of water (15 parts per billion!) (21).
The proprietary silver compounds Certisil and Micropur, used
to disinfect water, are effective against Bovine Enterovirus, Vacciniavirus
(cowpox), Influenza A and Pseudorabies virus (21).
In short, as pioneering silver researcher Dr. Henry Margraf
has stated, "Silver is the best all round germ-fighter we have." (13).
Historically,
Silver has been used in 20th Century medicine in a
wide variety of forms. It has been used as silver salts (e.g. Silver nitrate,
Silver
phosphate, Silver iodide, etc.) and Silver compounds (e.g. Silver sulfadiazine,
Silver
arsphenamine, zinc-Silver allantoinate) (11). Many of the doctors using silver in
the first half of the 20th century preferred a colloidal form of Silver , either
chemically or electrically produced (3,11). Mild silver protein and strong
silver protein (Silver combined with proits broad spectrum of action. It has been
claimed to kill some 650 different disease organisms (13). And unlike
antibiotics, Silver is an 'equal opportunity destroyer' - it doesn't discriminate,
but effectively kills germs of all major types: gram-positive and gram-negative
bacteria, spore-forming bacteria, fungus/yeasts, viruses and protozoal
parasites. Silver sulfadiazine (Silvadene¨), used almost universally in hospitals
to prevent serious burn infections (11), kills dozens of different bacteria
(11,14,16); it also kills 95% of 72 strains of herpesvirus (15), as well as the
protozoal parasite Plasmodium berghei (malaria) (17). Silvadene¨ also kills
various yeasts, including several Aspergillus varieties, Mucor pusillus,
Rhizopus nigricans and 50 different clinical isolates of Candida albicans (18).
Silver salts never achieved widespread use in medicine for
several reasons. As Grier notes, "Water-soluble ionized preparation [i.e.
silver salts] are generally corrosive, irritating and astringent." (11).
Silver
nitrate is notorious for being irritating to tissue and staining everything it
touches (13). Also, silver salts are often not as effective as colloidal Silver or
Silver proteins. For example, Simonetti and colleagues tested extremely dilute
solutions of electro-colloidal Silver [Ag(e)] and Silver nitrate [Ag N03] against
culture of two bacteria (E. coli and P. aeruginosa), a yeast (C. albicans) and a
mould (A. niger). The levels of Silver ion tested were incredibly low: 108 PPB
(0.108mcg/ml) and 10.8PPB (0.0108 mcg/ml). Simonetti et al concluded "Our
experiments showed that the contact antimicrobial activity of Ag(e) was superior
to that of AgNO3 against gram-positive and negative bacteria, C. albicans, and a
filamentous mycete. Our contact tests confirmed the excellent antibacterial
spectrum and the high potency of electrically generated silver demonstrated
previously.... Anodic silver ions are very effective agents at low
concentrations without any detrimental effect upon normal mammalian cells, and
the [low] concentrations needed to inhibit the bacteria in invitro experiments
have been confirmed clinical data." (23).
Silver salts also tend to be more toxic than silver proteins and
colloidal silver. Thus, when Hussain et al tested AgNO3 on fresh human
lymphocytes, they found 90% lymphocyte destruction when they were exposed to 50
micromoles Silver as AgNO3 for two hours. Yet when lymphocytes were exposed to 1200
micromoles Silver as a Silver-cysteine complex, there was no significant impairment of
the lymphocytes at a silver dose 24 times greater than the AgNO3 provided (24).
Thus, both modern science and early 1900's medical practice
favor the use of either colloidal Silver or mild silver protein (strong silver
protein contains less Silver than mild silver protein, but is generally more
irritating to tissue [11]).
Electrically prepared colloidal silver [Ag(e)] is currently
available from many sources, in potencies ranging from 3-5 PPM up to 500 PPM.
Equally (or more) important than the silver level is the particle size and
degree of dispersion. In a liquid colloid, the Silver does not actually dissolve in
the liquid; rather, it exists as a suspension of microscopic particles floating
around in the liquid medium. Properly made Ag(e) should contain particles
approximately 0.01 to 0.001 microns in diameter (1 micron=one millionth of a
meter, or 4/100,000 inch). At this tiny size, each particle is a cluster of
perhaps 5-20 Silver atoms, with a positive electric charge. Because the particles
are so tiny (and thus light), and because the charged particles repel and
'bounce off' each other, they can defy gravity and remain suspended in their
water medium for months - even years when properly stored (away from light, at
room temperature). However, over time the Silver particles may gradually absorb onto
the walls of the container, gradually lowering the amount of Silver in suspension.
The most thoroughly dispersed Ag(e) should be yellow in color, as colloid
chemist H. Freundlich noted in 1992: "With increasing degree of dispersion
the color of silver sols [colloids] changes from grey green through lilac and
red to yellow." (25). Because each Ag(e) particle contains 5-20 Silver ions,
the particles act as a time-release mechanism to provide continuous germ-killing
Silver ion availability, as single Silver ions gradually break off from their parent
microclusters.
MILD SILVER PROTEIN: PROS & CONS
Mild silver protein (MSP) is made by various chemical
processes that ultimately create a 19-25% Silver content, the remainder being a
protein (11). Like Ag(e), MSP is also made in various potencies from 10 to 500
PPM Silver. The protein acts as a stabilizer and solubilizer for the Silver particles,
preventing them from combining with each other to form ever-larger particles
that would gradually settle out of suspension. Thus, the shelf-life of MSP is
generally longer than for Ag(e). DEDI guarantees its MSP to have a 6-year
shelf-life. The Silver protein combination aslo acts as a time-release mechanism to
gradually liberate Silver ions.
DEDI's MSP is produced in their FDA-licensed pharmaceutical
laboratory to stringent quality standards, since it is an OTC-licensed 'drug,'
Thus one can be more assured of the quality of DEDI's MSP than one can be of the
various Ag(e) products produced and sold by the health food industry, as they
are normally not produced in registered/licensed pharmaceutical labs.
HOW SAFE IS SILVER?
A hundred years of published clinical and experimental
research has demonstrated Silver to be a surprisingly safe substance, unlike its
heavy-metal cousins lead, mercury, cadmium and gold. In general, Silver salts are
more toxic than Ag(e) or mild Silver protein, but are still relatively non-toxic.
Thus Romans notes: "Sollman (1943) observed that silver nitrate in doses of
0.01 [10mg] to 0.1g [100mg] by mouth produces no symptoms and swallowing pieces
of [silver nitrate] pencils up to 2.5g is often harmless, but larger quantities
cause acute gastritis. These reactions are purely local. From 2 to 30g has
caused death within a few hours to a few days; 10g are generally fatal, but the
ingestion of 30g has been survived.... For many years silver compounds were
considered the most effective agents available for the prevention and treatment
of gonorrheal infections.... The silver proteinates, especially of the argyrol
type [i.e. mild silver protein], have been used extensively in the treatment of
infections of the mucous membranes of the eyes, ears, nose and throat. Thus it
has been shown that silver compounds are useful germicides and that effective
doses are harmless." (12).
Writing in the Lancet in 1912, physician C.E. MacLeod
reported based upon his widespread clinical use of chemically-produced colloidal
Silver that "They [silver 'collosols' of 500 PPM strength] may be applied
topically, hypodermically, intravenously, or by the mouth, and being non-toxic
the dose hypodermically is unlimited, and experimental injections of 1 to 2 c.c.
of 500 PPM Silver would supply 1/2
to 1mg Silver .
French physician B.G. Duhamel reported on the use of
Electrargol (an electro-colloidal Silver providing 400 PPM Silver) also in the Lancet in
1912. He stated that "They [Ag(e) preparations] are employed as a rule for
the sake of their constitutional effects, for which purpose an injection of from
5 to 20 c.c. [2 to 8 mg Silver] is made into muscle or... into the veins....
Similarly, the colloid [Silver] products can be injected... into the spinal canal (cerebro-spinal
meningitis).... the most remarkable effects follow the intravenous injection of
these colloids; indeed in some instances the patients have been rescued from
apparently inevitable death.... One point stands out prominently, and that is
the absolute innocuousness of these [Silver colloids], whether injected into the
veins or muscles or into the spinal canal.... the dose is determined solely by
the requirements of the case since they are devoid of toxicity."
T.H. Sanderson-Wells, reporting on the successful treatment
of a case of puerperal septicemia by injection of "collosol argentum"
(a 500 PPM chemical-colloidal Silver), noted that Ò20 c.cm. of collosol argentum
[=10 mg Silver] produced no untoward effects." (28)
Most of the quantitative safety data on
Silver comes from a large
number of animal studies done in the past century. Thus, "Huebner found
that with intravenous injection into rabbits the minimum lethal dose of the
non-colloidal silver thio-sulfate was 0.01 to 0.03 gram per kilo, while the
minimum lethal dose of colloidal silver was 0.065 gram per kilo." (27) This
would equate to an injection dose for a 70kg/154 pound human of 4550 mg.
M.S. Wysor tested high doses of
Silver sulfadiazine (30% Silver) in
mice every day for a month. He reported that "Doses of 1,050 mg/kg when
administered by oral and subcutaneous routes were not toxic.... No deaths
occurred within the two experimental groups ... during the 30-day test
period.... At the end of the test period, all the animals were sacrificed and
tissue sections sent to the Department of Pathology for analysis. Histological
studies showed that there was no obvious pathology in any of the groups
receiving silver sulfadizine for the test period. There was no weight loss in
any of the groups and no evidence of behavioral changes. None of the animals
exhibited diarrhea." (17). A 1,050 mg/kg dose of Silver sulfadiazine would
translate into roughly 22 grams of elemental Silver for a 70kg/154 pound person.
Hill and Pillsbury report results of many animal
Silver toxicity
studies in their 1939 book on Silver. For example, "Lentz has administered a
saturated solution of a silver oxide containing 1.52 grams per liter
intravenously in doses as large as 4 c.c. three times daily for a period of
three weeks to various animals without producing any apparent toxic
effects." (7). An equivalent dose for a 70kg human would provide 1190 mg
Silver
daily.
"Gompel and Henri studied the effects of repeated
injections of a dilute colloidal silver solution over long periods in guinea
pigs. Using a solution containing 0.25 gram in 1000 c.c. [=250 PPM Silver] they
found that the intravenous administration of 1 or 2 c.c. to guinea pigs daily
for two months caused no particular symptoms [= approximately 17.5 to 35 mg Silver
daily for a 70 kg person]. This was also true in rabbits when 10 c.c. were given
intravenously for 10 days [=approximately 88 mg Silver daily for a 70 kg
human]." (7).
"To a series of 16 rabbits, massive doses of 66.7 mgm.
of silver arsphenamine per kilo were administered [intravenously] at intervals
from three to seven days. In a series of four rabbits, relatively excessive
doses of 10 mgm. per kilo were given. The minimal dose given was a total of 227
mgm. of the compound in 47 days.
The silver content of the drug was 14.5%.... Hooper and
Meyers found that silver arsphenamine did not produce any diffuse kidney lesions
and that the... cells of the liver were in all cases well preserved. The
majority of the rabbits showed a gradual increase in hemoglobin and red blood
cells during the experiment, while the white cell count and the differential
cell count remained within normal limits.
From this study it is seen that in spite of the
administration of silver arsphenamine in amounts far exceeding that employed
clinically [in humans], no significant toxic effects were observed." (7).
The total silver amounts used in this experiment would equate to a minimum of
2304 mg Silver to a maximum of 23.98 grams Silver for a 70kg human.
By now the point should be clear: especially when taken
orally, silver is a reasonably non-toxic metal for humans, and is even fairly
non-toxic when injected, especially at the modest dosage level of 10 mg daily or
less. Early 1900's silver injection medical protocols typically provided 1-10 mg
Silver daily, sometimes more.
ARGYRIA: THE DARK (BLUE-GREY) SIDE OF SILVER
Given the broad range of silver's efficacy against germs -
even antibiotic-resistant ones - and it's relatively high degree of safety, one
might wonder why Silver isn't routinely used by every doctor and hospital in the
world today.
Aside from the seemingly cynical (but all too true) reason
that the medical-industrial complex would lose revenue (sickness pays, wellness
doesn't, and a single pill of a modern 'high-tec' antibiotic typically sells for
$10-20), there is a more legitimate cosmetic reason for caution in Silver use: the
phenomenon known as argyria. When sufficiently large quantities of Silver accumulate
in the body, some of it accumulates just beneath the surface of the skin, which
may lead to a permanent bluish-grey tinge to the skin.
As Hill and Pillsbury (both M.D.s) note in their
massively researched (601 references) 1939 book Argyria, "A striking
feature of argyria is the absence of any evidence that the deposits of silver
produce any significant physiologic disturbance of the involved organs or
tissue.... Aside from the [Silver] pigment deposit, the gross and microscopic
appearance of the involved tissues is normal. Argyria is, therefore, of
significance only from the standpoint of cosmetic appearance." (7).
In their chapter on
Silver in the 1986 Handbook on the Toxicology
of Metals, Fowler and Nordberg also remark that "argyria... is bluish-grey
discoloration of the skin.... Although not esthetic, this condition is
considered harmless.... a total dose of 1-8 g Silver would be required to induce the
condition in a long-term inhalation exposure situation. The dosage required to
induce argyria by ingestion seems to be somewhat higher, i.e. between 1 and 30 g
of soluble silver salts...."(29).
Hill and Pillsbury could only find 239 reported cases of
argyria by 1939, in spite of silver's widespread medical and over-the-counter
use in America and Europe during the previous 40 years. Only 16 cases occurred
from less than one year's chronic use of Silver; about half occurred with 3 years or
less of chronic Silver use; and about half of all cases involved chronic Silver use
ranging from 3 to 25 years. Where the published information (214 cases) provided
data on the Silver compound used, 55% (118) of the argyria cases were caused by
Silver
nitrate; 13% (28) were caused by Argyrol, a mild Silver protein; 9% (19) were caused
by Silver arsphenamine; 6% (13) were caused by Collargol, a chemically
produced colloidal Silver, and various other products caused the remainder of
reported argyria cases (7). In their summary Hill and Pillsbury report that a
safe (with respect to argyria) total dose of the intravenous drug Silver
arsphenamine would be 6 grams (.9 grams Silver ), while with Silver nitrate "the
danger of argyria is very slight if the total amount injested by mouth is below
six grams [3.8 grams Silver]."(7).
To put this in perspective: if one assumes that
electrocolloidal Silver and mild Silver protein are equally prone to cause argyria
compared to Silver nitrate (and they probably are actually less prone to promote
argyria), then it would take 11.5 years of daily oral use of two tablespoons of
30 PPM Silver to reach the 3.8 gram Silver threshold. Thus the risk of developing
argyria from occasional use of Silver to treat specific infectious conditions must
be considered virtually non-existent. I have used colloidal Silver intermittently
since 1994, sometimes taking 2-3 tablespoons of 30 PPM Silver daily for months at a
time, consuming about 250 mg Silver total, and I do not exhibit the slightest hint
of argyria.
ARGYRIA: REDUCING THE RISK
The two simplest methods to reduce argyria risk are:
1) Do not use AgNO3 internally - it's the best reported
promoter of argyria.
2) Limit use of colloidal
Silver /mild Silver protein products to at
most several weeks to several months at a time. Do not take oral (or intravenous
or intranasal) Silver on a permanent, ongoing basis unless carefully monitored by
and under the supervision of a physician who is knowledgeable in Silver use and
argyria.
The dietary supplement
N-Acetyl cysteine may also
provide significant protection against Silver accumulation and thus argyria. Fowler
and Nordberg state that "Alexander and Aeseth (1981) reported that rats
injected intravenously with silver nitrate excreted silver in the bile mainly
bound to a low molecular-weight complex which appeared to be glutathione."
(29). Glutathione is a tripeptide composed of glutamic acid, glycine and
cysteine. Based on their study of the protective effect of N-Acetyl
cysteine against various
toxic agents, Dawson et al reported: "The protective effect [of N-Acetyl
cysteine] in
some cases is due to the free sulfhydryl group which N-Acetyl cysteine contains,
and in other cases it is due to its role as a precursor for cysteine in [ Glutathione]
biosynthesis." (30).
Bergstrom and colleagues remarked that "...oral NAC in
fact offers prompt availability of thiol groups needed for [GSH] biosynthesis in
the hepatic cells where the need is highest." (31).
Lorber et al stated that "Our in-vitro studies
demonstrated that NAC effectively complexes gold, mercury and silver.... Our
[clinical] findings suggest that NAC may be a promising and effective treatment
of gold [and thus presumably Silver] intoxication.... The use of N-Acetyl
cysteine
may thus afford better detoxification for... heavy metal poisoning than other
available agents in current use." (32). In order to avoid cancelling out
the microbicidal effect of Silver, it would probably be best to wait until a given
course of Silver treatment is complete, then begin taking 200-600 mg NAC two or
three times daily with meals. This will enhance clearance of any residual Silver
from the body, thus reducing the risk of argyria.
WHAT IS SILVER USED FOR?
Colloidal
Silver and mild Silver protein (MSP) are useful in treating
virtually any infectious condition; they were used to treat literally hundreds
of infectious conditions from 1900 to 1940 (3,4,5,6,7,11,12,28). In a 1998
report on its MSP product Silvicidal ES¨, DEDI states that "Trials with
Silvicidal ES¨ formulations have shown this product to be effective against
general internal and topical infections, namely:
*
Ear infections
*
Thrush/Candida (consult a physician before use)
*
Common Colds
*
Staph infections
*
E. Coli infections
*
Intestinal infections
*
Sinus infections
*
Leukemia
*
HIV
*
Lyme's disease
*
Viral infections
*
Herpes
*
Gingivitis
*
Food poisoning
NOTE: Silvicidal ES¨, if taken at onset of common cold, is
effective, however, it is not effective once the cold has set in. However,
Silvicidal ES¨ is effective with most flu varieties after the flu has set in.
In both cases, flu and the common cold, Silvicidal ES¨ works best if taken as a
preventative, or at the first sign of symptoms." Also in the Silvicidal ES¨
report, Dr. J.J. Cardot states that "Due to the non-toxic properties of
Silvicidal ES¨, the physician is prudent to prescribe doses that are higher
than needed rather than givin too small an amount. The exception... is when a
systemic fungal infection is known or suspected. In these cases one should start
with a low dose (1Ú16 teaspoon per day) for three days; increasing the dose in
1Ú16th increments until the infection is cleared from the body. [This] approach
will prevent a severe Herxheimer reaction. The dose suggested should be adjusted
to the severity of the symptoms and the general condition of the patient's
overall health."
USES AND DOSES
Silver may be dropped into the ear several times daily for ear
infections. Silver may be snorted into the nostrils from a nasal squirt-bottle for
sinus infections or to abort head-colds. A dilute Silver solution (5-10PPM) may be
dropped into the eyes to treat conjunctivitis or to soothe inflamed, itchy eyes
(there may be a brief initial mild stinging sensation). Silver may be swabbed or
rubbed (possibly mixed with aloe-vera gel, ideally fresh-squeezed from an aloe
plant) onto minor burns, cuts, scrapes, wounds, etc. to prompt healing and
prevent heal/infection. Silver may be massaged into gums several times daily for
dental infections.
Silver is also useful to treat animal (farm or pet) infections as
well, although dose should be scaled down or up (compared to human weight/dose)
depending on the weight of the animal.
Silver has also been used as a water purifier since 1900 or so;
since the 1930's Silver has been used to impregnate water filters to kill germs in
the water or which might grow in the filter medium (11,12,21). The consensus of
water treatment experts is that as little as 0.05 to 0.5 PPM is sufficient to
kill most bacteria within several hours (11,12,21). Protozoal parasites (Giardia,
Entamoeba, Paramecia, etc.) may require higher levels - e.g. 5-30 PPM (22). To
germicidally purify water of doubtful quality, add 1 to 3 teaspoons of 10-50 PPM
Silver to a pint of water; stir thoroughly and let stand for several hours. This is
only a general guideline - when in doubt increase the Silver dosage as you see fit.
To conclude this report on a personal note: I have found
Silver
to indeed be a 'master germicide.' I have personally aborted colds with liquid
Silver (I have just done it again while writing this report); I have had great
success controlling candida with Silver. I routinely use liquid Silver or
Silver gel for
cuts, burns, etc. and have found it to be almost immediately soothing, as well
as anti-infective/pro-healing. My wife routinely squirts Silver into her nose when
flying to avoid catching cold from the plane's germ-laden recycled air.
The most amazing case of
Silver use which I've had personal
knowledge involved an 83 year old woman who was suffering severe septicemia
(infectious blood poisoning). Her doctors were unable to control the raging
infection and had sent her home, expecting her death in 48-72 hours. Her husband
contacted an intermediary, through whom I recommended trying Silver . The woman was
immediately put on one tablespoon of 5PPM colloidal Silver three times daily. Within
24 hours her septicemia began to disappear, and within 48 hours her septicemic
crisis was over, and she did not die as 'expected.'
TECHNICAL NOTE
Most
Silver preparations express their Silver content in
parts-per-million (PPM). 1 PPM = 1 microgram (mcg) Silver per cc = 5 mcg Silver per
teaspoon = 15 mcg Silver per tablespoon. 30 PPM = 30 mcg Silver per cc = 150 mcg
Silver per
teaspoon = 450 mcg per tablespoon, etc.
IREFERENCES
1)
H. Bechhold, Colloids in Biology and Medicine, N.Y.: D. van Nostrand,
1919, pp. 364-76.
2) N.R. Thompson, Comprehensive Inorganic Chemistry, Vol. 5,
ch.28, Elmsford, N.Y.: Pergamon Press, 1973.
3) B. Duhamel (1912) "Electric Metal Colloids and Their
Therapeutical Applications" Lancet, Jan. 13.
4) A. Searle, The Use of Colloids in Health and Disease,
London: Constable & Co., 1920, pp67-111.
5) A. Legge Roe (1915) "Collosol Argentum and its
Opthalmis Uses" Br. Med. J., Jan.16, 104.
6) G. van Amber Brown (1916) "Colloidal Silver in
Sepsis" Am. J. Obstetrics, Jan-June, 136-141.
7) W. Hill & D. Pillsbury, Argyria - The Pharmacology of
Silver, Baltimore: Williams & Wilkins, 1939.
8) S. Begley (1994) "The End of Antibiotics"
Newsweek, Mar. 28, 46-51.
9) J. Fisher, The Plague Makers, N.Y.: Simon & Schuster,
1994.
10) D. Long & S. Spencer Jones, Bioterrorism: Secrets for
Surviving the Coming Terrorist Germ Warfare Attacks on U.S. Cities, Barstow, CA:
Life & Health Research Group, 1998.
11) N. Grier (1983) "Silver and Its Compounds" in
Disinfection, Sterilization and Preservation, S. Block, ed., Philadelphia: Lea
& Febiger, 380-428.
12) I. Romans (1954) "Silver Compounds" &
"Oligodynamic Metals" in Antiseptics, Disinfectants, Fungicides and
Chemical and Physical Sterilization, G. Reddish, ed., Philadelphia: Lea &
Febiger, 380-428.
13) J. Powell (1978) "Our Mightiest Germ Fighter"
Sci. Digest, Mar., 57-60.
14) H. Carr et al (1973) "Silver Sulfadiazine: In Vitro
Antibacterial Activity" Antimicrob. Agents Chemother. 4, 585-87.
15) T.-W. Chang & L. Weinstein (1975) "Prevention of
Herpes Keratoconjunctivitis in Rabbits by Silver Sulfadiazine" 8, 677-78.
16) T.-W. Chang & L. Weinstein (1975) "Inactivation
of treponema Pallidum by Silver Sulfadiazine" 7, 538-39.
17) M. Wysor (1975) "Orally-Administered Silver
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302-10.
18) T. Wlodkowski & H. Rosenkranz (1973) "Antifungal
Activity of Silver Sulfadiazine" Lancet, Sep. 29, 739-40.
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Silver Ions: Quantitative Effects on Bacterial and Mammalian Cells"
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20) T. Berger et al (1976) "Antifungal Properties of
Electrically Generated Silver Ions" Antimicrob Agents Chemother 10, 856-60.
21) R. Thurman & C. Gerba (1989) "The Molecular
Mechanisms of Copper and Silver Ion Disinfection of Bacteria and Viruses"
CRC Crit Rev Envir Control 18, 295-315.
22) W. Newton & M. Jones (1949) "Effectiveness of
Silver Ions Against Cysts of Endamoeba Histolytica" 41, 1027-34.
23) N. Simonetti et al (1992) "Electrochemical Ag+ for
Preservative Use" Appl Environ Microbiol 58, 3834-36.
24) S. Hussain et al (1992) "Cystein Protects Na, K-ATPase
and isolated Human Lymphocytes from Silver Toxicity" Biochem Biophys Res
Comm 189, 1444-49.
25) H. Freundlich, Colloid & Capillary Chemistry, N.Y.:
E.P. Dutton, 1922, p.385.
26) C.E.
MacLeod (1912) "Electric Metallic Colloids and Their Therapeutical
Applications" Lancet, Feb. 3.
27) A. Clark (1923) "The Properties of Certain
'Colloidal' Preparations of Metals" Br Med J, Feb. 17, 273-77.
28) T. Sanderson-Wells (1916) "A Case of Puerperal
Septicemia... Treated with... Collosol Argentum" Lancet, Feb. 16, p.258.
29) B. Fowler & G. Nordberg (1986) 'Silver'' in Handbook
on the Toxicology of Metals, L. Friberg, G. Nordberg & V. Vouk, eds.
Amsterdam: Elsevier Sci. Pub., Vol. 2, 521-31.
30) J. Dawson et al (1984) "The Effectiveness of N-acetylcysteine...."
Arch Toxicol 55, 11-15.
31) L. Borgstrom et al (1986) "Pharmacokinetics of N-acetylcysteine
in Man" Eur J Clin Pharmacol 31, 217-22.
32) A. Lorber et al (1973) "Clinical Application for
Heavy Metal-Complexing Potential of N-acetylcysteine" J Clin Pharmacol 13,
332-36.
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